(off)Targeting UPR signaling: the race toward intervening ER proteostasis
نویسندگان
چکیده
منابع مشابه
XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
The ability to ensure proteostasis is critical for maintaining proper cell function and organismal viability but is mitigated by aging. We analyzed the role of the endoplasmic reticulum unfolded protein response (UPR(ER)) in aging of C. elegans and found that age-onset loss of ER proteostasis could be reversed by expression of a constitutively active form of XBP-1, XBP-1s. Neuronally derived XB...
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The unfolded protein response of the endoplasmic reticulum (UPR(ER)) is a conserved signaling circuit that ensures ER protein homeostasis (proteostasis). In the UPR(ER) of higher eukaryotes, multiple sensors cooperatively perceive proteostatic disturbances in the ER lumen and induce downstream adaptive changes. Besides direct proteotoxic insults, altered lipid profiles can also lead to UPR(ER) ...
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ژورنال
عنوان ژورنال: Expert Opinion on Therapeutic Targets
سال: 2017
ISSN: 1472-8222,1744-7631
DOI: 10.1080/14728222.2018.1420169